Harbor Isle is a hamlet and census-designated place in the Town of Hempstead in Nassau County, New York, United States. The population was 1,436 at the time of the 2020 census. In the 1950s, a proposal was made for Harbor Isle to be annexed by the adjacent village, Island Park. The proposal ultimately was defeated, and Harbor Isle remains an un…Harbor Isle is a hamlet and census-designated place in the Town of Hempstead in Nassau County, New York, United States. The population was 1,436 at the time of the 2020 census. In the 1950s, a proposal was made for Harbor Isle to be annexed by the adjacent village, Island Park. The proposal ultimately was defeated, and Harbor Isle remains an unincorporated hamlet to this day.