Chip Chick on MSN7mon
The Colorado River Toad Secretes A Potent Poison That Has Psychedelic Properties And May Be Helpful In Treating Anxiety And Depression
The researchers extracted the poison from the toad’s secretions and used mice to see how it would interact with a serotonin ...
pharmaphorum3d
Exscientia starts trials of AI-designed Alzheimer's drug
According to the partners, DSP-0038 combines serotonin 5-HT2A receptor antagonism and 5-HT1A receptor agonism – two well established targets for antipsychotic drugs – in a single small molecule.
Nature4y
Focusing on women: creating new solutions for sexual dysfunction
In these women, sublingual testosterone can increase sensitivity to sexual stimuli, and a subsequent dose of a 5-HT1A-receptor agonist then inhibits the sexual-inhibition mechanism. On the basis ...
Concordia University1y
Matthew Gardner
Si YG, Gardner MP, Tarazi FI, Baldessarini RJ, Neumeyer JL (2007). R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands. Bioorg Med Chem Lett 17:4128-4130.
Nature5y
Reduction of L-DOPA-induced dyskinesia in animal models of Parkinson disease
In a follow-up study, Muñoz et al. investigated the effect of 5-HT-receptor blockade in macaque and rat models of PD with L-DOPA-induced dyskinesia. The authors then tested prolonged ...