CCR2 was highly expressed on malignant monocytes from AML patient samples, with cases of acute monocytic leukemia (M5) and acute myelomonocytic leukemia (M4), showing the highest levels of expression.

The monocytic leukemia zinc-finger protein (MOZ) gene is rearranged in t(8; 16)(p11; p13) and inv(8)(p11q13) associated with acute myeloid leukemia. The other fusion partners involved are CBP and ...

THP-1 = Human acute monocytic leukemia cell line. Disclosure: Research in Kris Chadee's laboratory is supported by grants from the Crohn's and Colitis Foundation of Canada, the Canadian Institute ...

Hyperleukocytosis is often seen in monocytic variants and can be ... DIC is also observed in patients with AML, in particular, acute promyelocytic leukemia (APL or M3-AML). These patients are ...

Revumenib displayed promising anti-tumor activity among patients with relapsed or refractory KMT2Ar acute leukemia.