The validity as well as the usefulness of measuring components of the renin-angiotensin-aldosterone system in the diagnosis and treatment of patients with elevated blood pressure (BP) has been ...

Renal hypoperfusion occurs as a result of reduced cardiac output, resulting in the activation of the renin–angiotensin–aldosterone system, which compensates for the hypoperfusion. However ...

The two primary mechanisms — considered “neurohormonal” responses — are activation of the sympathetic nervous system (SNS) and activation of the renin-angiotensin-aldosterone system (RAAS).

A high sodium intake inhibits the renoprotective effect of blockade of the renin–angiotensin–aldosterone system (RAAS). Vogt et al. investigated the combined effects of a low-sodium diet and ...

Lisinopril inhibits angiotensin-converting enzyme. It suppresses the renin-angiotensin-aldosterone system. The mechanism of the antihypertensive effect of thiazides is unknown. Fetal toxicity may ...

The dual-action agent LCZ696 blocks the angiotensin II receptor (via a valsartan moiety) and inhibits neprilysin (via an AHU377 moiety). In a phase II trial, this drug “demonstrated superior ...

[Hurst’s The Heart Section 11:13a,14a-b,15a] Although the renin-angiotensin-aldosterone system is activated in HFpEF, it is not as prominent as with systolic HF, and cardiac remodelling is less ...