Thus assays must measure antibody effector function, which may be mediated by direct neutralization, complement activation or antibody-directed cellular cytotoxicity. Direct viral neutralization ...

A recent study published in the journal Nature Communications observed antibody breadth and effector functions as important immune correlates that can be used to develop universal influenza vaccines.

This finding suggests that the antibodies can efficiently activate eosinophils and cause eosinophil-mediated clearance of target cells. Figure 6. Novel Fc effector functions of anti-CD20 mAbs.

“Our results suggest that, given that effector function is not required for efficacy [in treating ... Clinical research has mostly focused on targeting amyloid-β with antibody therapies, and several ...

Antibodies of the IgG4—but not the IgG1 ... acid mutation in the CH2 region of IgG4 designed to further reduce effector functions. Moreover, IgG4-PE had the additional IgG4-stabilizing serine ...

Structural and functional analyses identify a new family of bifunctional cell-wall-targeting type VI secretion system (T6SS) effectors and a surface-charge-engineering strategy that expands T6SS ...