So he wanted to produce molecules that activated only the AT2 receptor but not the other receptor, the AT1 receptor, as this would instead lead to problems such as an unwanted rise in blood pressure.

A depiction of the AT2 receptor (gray spirals and filaments) extending through a cell membrane; the blue ovals represent the membrane's inner and outer surfaces. A potential drug compound is bound ...

Vasoconstriction may reflect the absence of demonstrated vasodilatory T3 effects on vascular smooth muscle cells or may be the result of a higher circulating noradrenaline level and increased AT1 ...

Co. Ltd. has developed new heterocyclic compounds acting as angiotensin AT2 receptor antagonists reported to be useful for the treatment of neuropathy and neuropathic pain.