An innovative CRISPR-Cas12f-based activator system may hold significant potential in the future of gene therapy and biological research, suggest researchers of a new study. The study highlights the ...

The ability to control gene expression across a wide range is crucial for many fields, including bioengineering, disease detection, and environmental monitoring. Research led by Lingchong You, Ph.D., ...

Cognitive decline associated with aging is caused by the loss of cholinergic nerve supply to the hippocampus of our brain. Since the hippocampus is the center of learning and memory, a reduction in ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease. The findings, ...

Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease. The findings, ...

The study combines a deep learning model with CRISPR screens to control the expression of human genes in different ways -- such as flicking a light switch to shut them off completely or by using a ...

Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor Hirohisa Ohno (Department of Life Science Frontiers at CiRA) recently led a ...

Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have developed a system that can detect a particular RNA sequence in live cells and produce a ...

ALBUQUERQUE, NM and MEMPHIS, TN – November 25, 2025 – Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms ...