A 14-year study tracking NfL levels in people with the HD gene shows this tiny protein can signal disease progression many ...

Huntingtin was the first disease gene mapped to a specific chromosome. How did scientists do it and what have we learned since then? HD is a rare, adult-onset, autosomal dominant, progressive ...

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a mutation in the gene called huntingtin on chromosome 4. HD is inherited in an autosomal dominant fashion, so that each ...

Individuals who have an affected parent have a 50% chance of inheriting the gene mutation for HD and have the option to pursue genetic testing. [24] A person who has the HD mutation has a 100% ...

Family A has a strong family history of HD; multiple family members from at least 4 generations have been diagnosed with HD. In one generation, 8 of the 11 siblings had HD. The 3 family members ...

Because of the high frequency of the Huntington's disease gene in this population, some of the spouses of affected individuals have also descended from identified HD gene carriers. In none of ...

Latus Bio, Inc. (Latus), a biotechnology company pioneering advances in AAV gene therapy, is pleased to announce data presentations in support of its preclinical drug candidate at the 20th Annual CHDI ...

LETI-101 has demonstrated therapeutically relevant reductions of mutant huntingtin (HTT) protein, exceeding 80%, while preserving essential ...

“As someone who has devoted my career to Huntington’s disease (HD), I am tremendously excited about the advancements we've made in developing a gene therapy that targets the somatic ...