University of Iowa-led study has revealed the unexpected structure adopted by the ... understand how RAD52 functions at the ...

Both lead optimization (the process by which a small organic molecule is refined ... for activities against drug targets), are greatly aided if the three-dimensional structure of the biological ...

Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...

In this study, the research team applied machine learning to distinguish the molecular signature in the orbitofrontal cortex, a brain region critical for aspects of impulse control, drug-seeking ...

Researchers have found a unique molecular signature and genes in the orbitofrontal cortex associated with heroin-seeking behavior. A preclinical rodent model implicated a gene called Shisa7 as the ...

In this study, the research team applied machine learning to distinguish the molecular signature in the orbitofrontal cortex, a brain region critical for aspects of impulse control, drug-seeking ...