Huntingtin was the first disease gene mapped to a specific chromosome. How did scientists do it and what have we learned since then? HD is a rare, adult-onset, autosomal dominant, progressive ...

This review discusses the current and emerging gene and cell therapy strategies for Huntington's disease (HD), a ...

"No previous study has found any gene of significant effect on IQ, even though we know intelligence is heritable." Huntington's disease is caused by a mutation in the huntingtin (HTT) gene.

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the abnormal expansion of CAG repeats in the Huntingtin gene (HTT ...

The disease is caused by a mutation in the gene coding for huntingtin, which causes the formation of an abnormally long and unstable form of the protein that is chopped up by cellular repair ...

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a mutation in the gene called huntingtin on chromosome 4. HD is inherited in an autosomal dominant fashion, so that each ...

U.S. Food and Drug Administration (FDA) agrees that data from ongoing Phase I/II studies compared to a natural history external control may ...

The defect that causes the neurodegenerative disease Huntington's has been corrected in patients for the first time, the BBC has learned. An experimental drug, injected into spinal fluid, safely ...

Based on the recent study, therapeutic strategies (such as antisense gene therapy) that do not discriminate between normal and mutant huntingtin 12 may further exacerbate the disease. Thus ...