Huntingtin was the first disease gene mapped to a specific chromosome. How did scientists do it and what have we learned since then? HD is a rare, adult-onset, autosomal dominant, progressive ...

A longstanding enigma in Huntington's disease is how the mutated protein derived from the huntingtin gene is present in every cell of the body, but the disease appears to selectively affect ...

This diagram represents a small part of a much larger ... The data were analyzed for linkage to the Huntington's disease gene using the program LIPED with a correction for the late age of onset.

LETI-101 uses CRISPR to target the gene that codes for huntingtin. The company has also been in talks with the U.K.’s Medicines and Healthcare products Regulatory Agency (MHRA) to discuss the ...