The paper S. Kaur et al., “An unmet actin requirement explains the mitotic inhibition of clathrin-mediated endocytosis,” eLife, 3:e00829, 2014. For decades, scientists observed clathrin-mediated ...

In endocytosis, the cell takes in materials from outside by wrapping them within vesicles, which carry them to the lysosome for breakdown. In phagocytosis, immune cells such as macrophages act ...

This study reveals that prion protein (PrP) promotes copper toxicity in Wilson disease by facilitating copper endocytosis. The authors demonstrate that suppressing PrP reduces copper overload and ...