have become popular in antibody therapeutics. Compared to conventional monospecific antibodies, multispecific antibodies have become a primary focus area for biotech and big pharmaceutical ...

Paragon has agreed not to generate any new anti-IL-17A/F monospecific antibodies for at least five years within the same field. Oruka Therapeutics is obligated to pay Paragon royalties on sales of ...

In preclinical studies, GB261 showed enhanced tumor cell killing relative to anti-CD20 monospecific antibodies and enhanced safety–efficacy balance relative to a positive control BsAb ...

No writing assistance was utilized in the production of this manuscript. Monoclonal antibodies are novel therapeutic agents used with great success in the treatment of rheumatoid arthritis (RA).

The properties of the different IgG isotypes should be considered in developing therapeutic antibodies. To address this problem, antibody engineers introduced a serine-to-proline substitution that ...

In addition, it develops INCAGN1876, a GITR agonist; INCAGN2390, a TIM-3 monospecific antibody; INCAGN2385, a LAG-3 monospecific antibody; MK-4830, a monospecific antibody targeting ILT4 that is ...

Tharimmune (THAR) announced the expansion of its product pipeline with HS1940, a dual-target multispecific biologic engineered to bind to both ...

resulting in unique mechanisms of action not accessible through typical monospecific antibodies. Azymetric antibodies can block multiple signaling pathways, recruit immune cells to tumors ...

Clinical validation of the Azymetric platform is demonstrated by the accelerated approval of Ziihera® (zanidatamab-hrii), a treatment for advanced HER2-positive biliary tract cancer in adults who have ...