RPA has a higher affinity for ssDNA than Rad51, and it therefore can inhibit recombination by blocking Rad51's access to the single strand needed for invasion. In yeast, however, binding of Rad51 ...

RAD51 is a protein involved in homologous recombination repair (HRR) alterations. Developed in-house by Serra's laboratory, the RAD51 assay is based on the detection of this protein as a ...

When the Shu complex is present, it helps guide RPA to move along the DNA strand, allowing for more efficient repair. "We knew that RAD51 and RPA were related to the Shu complex, but no one had ...

Biochemically, the path chosen depends on the nature of the complex that assembles after the RPA–ssDNA complex — Rad52 promotes annealing and Rad51 promotes DNA strand invasion. Finally ...