A typical footprinting experiment involves radioactive labeling of the DNA region of interest—usually a larger chunk of DNA suspected to contain one or more transcription factor binding sites.

A multi-institutional team of investigators have developed a catalog of transcription factor binding sites that regulate gene ...

One distinct feature of transcription factors is that they have DNA-binding domains that give them the ability to bind to specific sequences of DNA called enhancer or promoter sequences.

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

Researchers at the University of California at San Francisco have identified an RNA-binding protein that increased the translation of Myc mRNA. The authors wrote that their work, which was published ...

"This surprising discovery points to a small but crucial feature of the transcription factors: their START domain," a lipid-binding region within the TFs, which the researchers liken to a foreman ...

The transcription factor regulatory network in Pseudomonas aeruginosa is complex and involves multiple regulators that respond to various environmental signals and physiological cues by regulating ...

C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic ...

Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements.

A research team at KAIST has identified the core gene expression networks regulated by key proteins that fundamentally drive ...

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that ...