BMJ

The immunogenicity of anti-TNF therapy in immune-mediated inflammatory diseases: a systematic review of the literature with a meta-analysis

Background Immunogenicity of aTNFs is one of the mechanisms behind treatment failure. Objective To assess the effect of anti-drug antibodies (ADA) on drug response to infliximab, adalimumab and ...
BMJ

Efficiency of tofacitinib in refractory interstitial lung disease among anti-MDA5 positive juvenile dermatomyositis patients

Correspondence to Professor Caifeng Li, Department of Rheumatology, Beijing Children's Hospital, Capital Medical University, National Centre for Children’s Health, Beijing, 100045, China; ...
BMJ

Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic ...

Objectives To perform a genome-wide association study (GWAS) of gout cases versus asymptomatic hyperuricaemia (AH) controls, and gout cases versus normouricaemia controls, and to generate a polygenic ...
BMJ

In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells

Correspondence to Professor Xuan Zhang, Department of Rheumatology & Clinical Immunology, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College, ...
BMJ

Ankylosing spondylitis: an overview

1 Department of Gastroenterology and Rheumatology, Free University, Berlin, Germany 2 Rheumazentrum Ruhrgebiet, Herne, Germany and Department of Gastroenterology and Rheumatology, Free University, ...
BMJ

Serum interferon-α levels and IFN type I-stimulated genes score perform equally to assess systemic lupus erythematosus disease activity

1 Sorbonne Université, Inserm, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Assistance Publique–Hôpitaux de Paris, Groupement Hospitalier Pitié–Salpêtrière, Département ...
BMJ

Stage-specific and location-specific cartilage calcification in osteoarthritis development

Correspondence to Professor Hongwei Ouyang, 1. Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, ...
BMJ

AB0664 Life expectancy in patient with giant cell arteritis (GCA): impact of vision loss

Background and purpose Several epidemiologic studies reported increased mortality in patients with GCA, while others found that the overall survival was essentially identical to that of the general ...
BMJ

IgM rheumatoid factor amplifies the inflammatory response of macrophages induced by the rheumatoid arthritis-specific immune complexes containing anticitrullinated protein ...

1 Unité Différenciation Épidermique et Auto-Immunité Rhumatoïde, INSERM Unité Mixte de Recherche 1056, Toulouse, France 2 Unité Différenciation Épidermique et Auto-Immunité Rhumatoïde, CNRS UMR 5165, ...
BMJ

Ruxolitinib as a salvage therapy in adult-onset macrophage activation syndrome: insights from eight cases

Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic disorder characteristic by excessive production of proinflammatory cytokines. In adults, MAS poses a major clinical ...
BMJ

Characterised intron retention profiles in muscle tissue of idiopathic inflammatory myopathy subtypes

Objectives Idiopathic inflammatory myopathies (IIMs) are a group of heterogeneous autoimmune diseases. Intron retention (IR) serves as an important post-transcriptional and translational regulatory ...
BMJ

Risk of high-grade cervical dysplasia and cervical cancer in women with systemic inflammatory diseases: a population-based cohort study

Correspondence to Dr Seoyoung C Kim, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA; ...