The protein 'MIPS' changes its internal structure when it becomes active. Its disordered active centre becomes a defined structure with special functions. The protein plays a key role in the ...

Inside each cell of the human body are proteins that control which genes are expressed at the right place and time. However, intriguingly, many of the most important proteins involved in gene ...

A new citizen-science project is investigating a possible universal structural pattern in protein 3D architecture; The pattern involves amino acids clustering by chemical type int ...

In the wee hours of an October morning, David Baker, a protein biologist at the University of Washington (UW), received the most-awaited phone call in a scientist’s career. Halfway around the world, ...

Using a tool to solve a protein's structure, for most researchers in the world of structural biology and computational ...

The genomes of phages—viruses that infect bacteria—are largely composed of "dark matter": genes that encode proteins whose functions remain unknown. Less than four years ago, a team led by Prof. Rotem ...

For years, biomolecular condensates were thought to be simple, liquid-like droplets with little internal organization. New ...

The “ChatGPT moment” for biology proceeds to unfold as protein language models, or machine learning tools trained on large databases of protein sequences, work to decode the language of life with the ...

Researchers combined AI simulations with NMR data to capture fleeting structures of intrinsically disordered proteins, offering new insight into protein misfolding linked to neurodegenerative diseases ...