Gut

From IPMN to invasive pancreatic cancer: new spatial insights

Early detection and interception of pancreatic ductal adenocarcinoma (PDAC) remain the only realistic strategies to reduce ...
Gut

Kupffer cell autophagy emerges as a central regulator of immune dysregulation in primary biliary cholangitis

Primary biliary cholangitis (PBC) is a rare chronic autoimmune cholangiopathy that mainly affects middle-aged women, ...
Gut

Post-infection disorders of gut-brain interaction: results of the Rome Foundation Global Epidemiology Study

Background Post-infection disorders of gut-brain interaction (PI-DGBI) are a subset of chronic gastrointestinal disorders triggered by acute infectious gastroenteritis. These conditions impose a ...
Gut

Real-world evidence supports earlier treatment in HBeAg-positive but not HBeAg-negative chronic hepatitis B virus infection

In chronic hepatitis B virus (HBV) infection, the central debate remains whom and when to treat. The 2025 European Association for the Study of the Liver (EASL) Clinical Practice Guidelines (CPGs)1 ...
gut.bmj

Antiviral therapy for chronic hepatitis delta: new insights from clinical trials and real-life studies

Chronic hepatitis D (CHD) is the most severe form of viral hepatitis, carrying a greater risk of developing cirrhosis and its complications. For decades, pegylated interferon alpha (PegIFN-α) has ...
gut.bmj

Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease

Objective Intestinal barrier loss is a Crohn’s disease (CD) risk factor. This may be related to increased expression and enzymatic activation of myosin light chain kinase 1 (MLCK1), which increases ...
gut.bmj

Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations

Objective Resection can potentially cure resectable pancreatic cancer (PaC) and significantly prolong survival in some patients. This large-scale international study aimed to investigate variations in ...
gut.bmj

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

1 Department of Gastroenterology and Hepatology, UMC Utrecht, The Netherlands 2 Department of Metabolic and Endocrine Diseases, UMC Utrecht and Netherlands Metabolomics Centre, The Netherlands 3 ...
gut.bmj

Piecemeal cold snare polypectomy versus conventional endoscopic mucosal resection for large sessile serrated lesions: a retrospective comparison across two successive periods

Correspondence to Dr Michael J Bourke, Gastroenterology and Hepatology, Westmead Hospital, WEstmead, NSW 2145, Australia; michael{at}citywestgastro.com.au Objective Large (≥20 mm) sessile serrated ...
gut.bmj

Underdevelopment of the gut microbiota and bacteria species as non-invasive markers of prediction in children with autism spectrum disorder

Correspondence to Professor Siew C Ng, Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong; siewchienng{at}cuhk.edu.hk; Dr Ruth Chan, Applied Biology and Chemical ...
gut.bmj

Recent advances in clinical practice: epidemiology of autoimmune liver diseases

2 Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK 3 Institute of Applied Health Research, University of Birmingham, Birmingham, UK Correspondence to Dr Palak J ...
gut.bmj

Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression

Objective Depression is associated with IBD, but the effect of antidepressants on IBD has been sparsely studied. We assessed the impact of depression and antidepressant therapies on the development of ...