A 91-year-old man with a history of bladder carcinoma and left total knee arthroplasty was evaluated because of left knee pain. A culture of synovial fluid showed no growth. A diagnosis was made.

This Sounding Board announces a new FDA policy that the default requirement for FDA approvals will be one robust pivotal trial plus confirmatory evidence, rather than two trials.

A 7-year-old boy was brought to a hospital with a 3-month history of cognitive deterioration and seizures. He had contracted measles at 7 months of age while living in an area where the infection is ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 20).

Trainees’ paths to safe, independent practice are variable. Artificial intelligence could help accelerate implementation of competency-based medical education to support individualized development.

When a physician’s own incidental finding sends her down a long and winding path to find answers, she finds herself overcome with worry — but also, eventually, a new appreciation for life.

The most important attribute of patient-centered care is the active engagement of patients when fateful health care decisions must be made — when they arrive at a crossroads of medical options, where ...

A high-school wrestler presented with an itchy rash that had worsened despite topical antifungal and glucocorticoid treatment. A circular, scaly plaque with papules, nodules, and pustules was seen ...

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 1).

Abstract To the Editor: We would like to address two potentially confusing issues concerning venous oxygen saturation (Svo 2) as presented in Table 1 of the review by Angus and van der Poll (Aug. 29 ...

Explore the current issue of The New England Journal of Medicine (Vol. 394 No. 6).