Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

Lysosomes are membrane-bound organelles whose acidic lumen (pH 4.5–5.0) is required for degradation. This luminal acidity is known to regulate cytosolic-side functions such as membrane fusion/fission, ...

Researchers have developed technologies that allow damaged proteins to be shredded or healthy ones installed. This may ...

All life on Earth shares a common ancestor that lived roughly four billion years ago. This so-called "last universal common ancestor" represents the ...

Ancient duplicated genes are giving scientists their first real clues about what life was like before all life on Earth shared a common ancestor.

Cancer cells have softer membranes than healthy cells. New nanoparticles exploit this physical difference to fuse selectively with tumors and deliver mRNA therapy with minimal off-target effects.

Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to ...

Knowing which lysosomal proteins are enriched in which brain cell types will help better understand contribution to neurological disorders.

Three Ohio State researchers earned the NAI fellow, the highest distinction awarded to inventors for their work in various fields. Dehua Pei, a professor in chemistry and biochemistry, was elected to ...

These include stress granules and proteasome storage granules (PSGs). In the past, these membraneless organelles were only visible as “droplets” using a fluorescence microscope. Now, researchers from ...

In A Nutshell As cells age, they deliberately shrink a major internal structure called the endoplasmic reticulum. This downsizing happens early in adulthood and shifts cells away from protein ...