Macrolide antibiotics like azithromycin rely on a complex ring structure that’s powerful but notoriously hard to control.  Researchers have uncovered how bacterial enzymes shape this ring during the ...

Crossplane KCL function allows developers to use KCL (a DSL) to write composite logic without the need for repeated packaging of crossplane functions, and we support package management and the KRM KCL ...

Background: Growing evidence suggests that body composition has a significant influence on cognitive function. However, their relationship remains controversial. This study investigated the ...

Objectives To evaluate the association between cardiorespiratory fitness (CRF) and cognition in a large sample of older adults, and to examine clinical and demographic factors that might moderate ...

PHILADELPHIA -- Intermittent calorie restriction improved executive function and memory measures in cognitively intact older adults, an exploratory pilot study suggested. The 8-week randomized ...

G protein–coupled receptors (GPCRs) allow cells to sense and respond to their environment and constitute the largest class of targets for approved therapeutic drugs. Temporally precise GPCR signaling ...

Effect of oncolytic herpes simplex virus on fusion-positive rhabdomyosarcoma to radiotherapy.

The receptor tyrosine kinase ROR2 mediates noncanonical WNT5A signaling to orchestrate tissue morphogenetic processes, and dysfunction of the pathway causes Robinow syndrome, brachydactyly B, and ...

Alpha-synuclein is a synaptic vesicle associated protein that is linked to a number of neurodegenerative disorders. In this manuscript, the authors provide compelling evidence of alpha-synuclein's ...

ABSTRACT: Apoptosis proteins have a central role in the development and homeostasis of an organism. These proteins are very important for the understanding the mechanism of programmed cell death, and ...