Early work in the 1980s, in which Orkin participated, identified one oral drug, hydroxyurea, that raises fetal hemoglobin ... a zinc molecule. Orkin's team has now reported the crystal structure ...

In sickle cell disease, a gene mutation causes the hemoglobin molecules ... protein wrapped around a zinc molecule. Orkin's team has now reported the crystal structure of the BCL11A tetramer ...

An ingenious large-scale experiment in Barcelona has led to the creation of a catalog detailing the effects of half a million ...

To unravel PfHO function, we first determined a 2.8 Å-resolution X-ray structure ... unusual molecular adaptations to survive and grow within heme-rich red blood cells. Hemozoin is the dominant fate ...

CD163, a macrophage receptor, is essential for clearing hemoglobin during hemolysis to prevent oxidative damage. Here, the authors reveal the cryo-electron microscopy structure of CD163 bound to ...

When you donate blood, you’re effectively losing blood. Iron plays a key role in maintaining adequate hemoglobin levels in your blood. This is important because hemoglobin is a protein in red ...

That protein is called hemoglobin, and in sickle cell disease, aberrant hemoglobin creates misshapen red blood cells. These cells will not easily bend or move and may obstruct blood flow, which can ...

AlphaFold solved a structural biology riddle: predicting protein structure. And yet, CASP, a global competition born to solve ...

National Cancer Institute researchers have developed a method called HORNET for characterizing 3D topological structures of large and flexible RNA molecules. Scientists used atomic force microscopy ...

Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announces positive results from two Phase I studies in ...