Most mutations which cause disease by swapping one amino acid out for another do so by making the protein less stable, ...

Early work in the 1980s, in which Orkin participated, identified one oral drug, hydroxyurea, that raises fetal hemoglobin ... a zinc molecule. Orkin's team has now reported the crystal structure ...

Beiliu City, located in the Guangxi Zhuang Autonomous Region, has a rich ethnic culture and diverse genetic background, which may contribute to a relatively high incidence of hemoglobin variants ...