People genetically susceptible to Huntington's disease often see their movement, mood, and cognition decline slowly over time ...

This review discusses the current and emerging gene and cell therapy strategies for Huntington's disease (HD), a ...

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the abnormal expansion of CAG repeats in the Huntingtin gene (HTT ...

The disease is caused by a mutation in the gene coding for huntingtin, which causes the formation of an abnormally long and unstable form of the protein that is chopped up by cellular repair ...

As we begin 2025, we look back on all of the Huntington’s disease research news and progress the field has made in the last ...

PTC518 is designed to reduce levels of the mutated huntingtin protein that leads to ... Novartis also licensed rights to a pair of potential gene therapies for Huntington's and SMA from Voyager ...

The balance of protein health within cells, a process known as proteostasis, is critical for maintaining cellular ...

Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to ...

Genetic variants that determine the shape of your teeth—including a gene inherited from Neanderthals—have been identified by a team co-led by UCL researchers. In a paper published in Current ...

Dec. 10, 2024 — In a single IV injection, a gene therapy targeting cBIN1 can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the ...