This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T H 1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 ...

Sayali is a high impact bio-pharmaceutical marketing leader with 12 years of U.S. commercialization experience, including leadership on a blockbuster brand. Currently, she serves as the Director of ...

By use of monoclonal antibodies to block these inhibitory signalling pathways, T-cell activation was restored and broad antitumour effects were observed clinically. Another immunotherapeutic strategy ...