At the junction of the lids and bases of the regulatory particles is Rpn10, which binds the polyubiquitins on targeted proteins. Other subunits in the regulatory particle release the ubiquitin and ...

(1) The lock-and-key model of protein interactions has dominated biology for more than a century, shaping how scientists study molecular communication and approach the development of novel ...

Biopharmaceuticals and biotherapeutics are medicines produced from living cells. But cells produce other proteins (called host cell proteins, or HCPs) that can contaminate the final therapeutic ...