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White House official lets slip 'top secret' modifications during planning meeting

White House director of management and administration Joshua Fisher signalled that it would 'make necessary security enhancements' - likely referencing the old bunker. Iran issues chilling threat if ...
C&EN

Modifications at C(5) of 2-(2-Pyrrolidinyl)-Substituted 1,4-Benzodioxane Elicit Potent α4β2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the ...

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, I-20133 Milano, Italy Institute of Neuroscience, CNR, Via Vanvitelli 32, I-20129 Milano, Italy Department ...
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Exploring a top cruise excursion in San Juan on Celebrity Apex

Explore the wonders of San Juan, Puerto Rico, as we experience natural rock slides at Las Playas, savor local cuisine at a traditional eatery, and visit Barrachina, known as the birthplace of the ...
C&EN

Modification at the C2′-O-Position with 2-Methylbenzothiophene Induces Unique Structural Changes and Thermal Transitions on Duplexes of RNA and DNA

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Article Views are the COUNTER-compliant sum of full text article downloads since ...
eLife

Predicting the effect of CRISPR-Cas9-based epigenome editing

This study presents an advance in efforts to use histone post-translational modification (PTM) data to model gene expression and predict epigenetic editing activity. Such models are broadly useful to ...