This study reveals that prion protein (PrP) promotes copper toxicity in Wilson disease by facilitating copper endocytosis. The authors demonstrate that suppressing PrP reduces copper overload and ...

In endocytosis, the cell takes in materials from outside by wrapping them within vesicles, which carry them to the lysosome for breakdown. In phagocytosis, immune cells such as macrophages act ...

Herpesvirus-encoded microRNAs (v-miRNAs) play a crucial role in modulating host cellular processes to promote viral persistence, immune evasion, and pathogenesis. These v-miRNAs function by targeting ...

The process of anthrax toxin action involves the following steps: Binding: PA binds to specific receptors on the surface of target cells, such as macrophages. Endocytosis: Once bound to the receptor, ...

Immunofluorescence: Quadriceps muscles were cryosectioned and co-stained overnight at 4°C with the monoclonal antibodies, F4/80 (1:100; D2S9R; Cell Signaling Technology) and DysB (1:25; Leica ...

Males with pulmonary arterial hypertension (PAH) have more proinflammatory macrophages — a type of immune cell — in the lungs than do females with the disease, a study suggests. Researchers identified ...

Macrophages represent one of the most prevalent cells in the colorectal cancer microenvironment and play a pivotal role in maintaining intestinal health and the development of colitis-associated colon ...

School of Biomedical Sciences, CUHK Shenzhen Research Institute, Heart and Vascular Institute, CUHK-GIBH CAS Joint Research Laboratory on Stem Cell and Regenerative ...

Department of Head and Neck Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center University of Electronic Science and Technology of China, ...

Future Microbiol. 2009;4(2):223-240.

More than half of patients with ischemic stroke experience futile reperfusion, increasing the risk of death and disabilities despite a successful recanalization. The reason behind this is debated, and ...