Cornell researchers have identified a specific brain circuit that could lead to anxiety treatments without cognitive side ...

Scientists have pinpointed a brain circuit that, when activated, reduces anxiety without impairing memory. Using ...

Weill Cornell Medicine investigators have identified in a preclinical model a specific brain circuit whose inhibition appears ...

A brand new candidate for weight-loss treatment is on the table, with scientists uncovering for the first time how a hormone ...

Among the many compounds under investigation, NMDA and metabotropic glutamate receptor antagonists and negative allosteric modulators appear particularly promising due to their ability to inhibit ...

Mark Bear of the Massachusetts Institute of Technology in Cambridge and his colleagues found that the lack of FMRP leads to dysregulation of signaling through the metabotropic glutamate receptors ...

and it will also work on a metabotropic glutamate receptor subtype 7 negative allosteric modulator (NAM). Both are in preclinical development. Other companies working on PAMs include Cerevel ...