In summary, extensive data support that titin’s passive force augments actomyosin interaction. At low passive force (short SLs), interactions between myosin heads and the A-band segment of titin may ...

We have identified a mutation in MYO6, a gene encoding a non-muscle or unconventional myosin, in all affected members of the pedigree. Familial hypertrophic cardiomyopathy (FHC) is typically confined ...

In addition to its major role at the uropod, Rho plays a dual role at the leading edge by promoting actin filament elongation via the formin mDia and by favoring membrane retraction via myosin ...