In summary, extensive data support that titin’s passive force augments actomyosin interaction. At low passive force (short SLs), interactions between myosin heads and the A-band segment of titin may ...

In addition to its major role at the uropod, Rho plays a dual role at the leading edge by promoting actin filament elongation via the formin mDia and by favoring membrane retraction via myosin ...

The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly ...

The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the ...