This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...

Targeted inhibition of a "signal jammer" protein may improve how tumors respond to immunotherapy. Published today in Nature, ...

Investigators found that lipid metabolism disruptions spark T-cell dysfunction in patients with chronic lymphocytic leukemia.

J Neuroinflammation © 2008 McCoy and Tansey; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons ...

Homologous recombination deficiency signature (HRDsig+) and the genomic landscape of clinically advanced prostate carcinoma (CAPC). This is an ASCO Meeting Abstract from the 2025 ASCO Genitourinary ...

Sweet taste receptors in the heart: A new pathway for cardiac regulation New research shows that the heart can sense sweeteners and can increase the force of heart muscle contraction in response ...

ROCKVILLE, MD – In a surprising discovery, scientists have found that the heart possesses "sweet taste" receptors, similar to those on our tongues, and that stimulating these receptors with sweet ...

Radiation influences some intracellular signaling pathways ... of interest. AT1, Alveolar type 1 cell; AT2, Alveolar type 2 cell; BAL, Bronchoalveolar lavage; ECM, Extracellular matrix; CCL, Chemokine ...

Cx40 (connexin 40) was reported to be a molecular modulator of the renal baroreflex. 6 Connexins are transmembrane gap junction proteins involved in cell-to-cell communication. Renin cell-specific ...

AGEs, Ang II, IL-1β and TNF-α etc, may trigger these two pathways to promote fibrosis and inflammation in diabetic kidneys. Abbreviations: AGEs, advanced glycation end products; RAGE, receptor for AGE ...