Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Institute of Intelligent Sport and Proactive Health, Department of Health and Physical Education, Jianghan University, Wuhan, China Sarcopenia and AD are both classic degenerative diseases, and there ...

- Muscle cells, also known as myocytes, are specialized cells designed for contraction and force production. Skeletal Muscle Cells: These cells are long, cylindrical, and have a striated (or striped) ...

The control of muscle contraction is usually described in terms of excitation–contraction coupling or muscle activation. Muscle relaxation has received much less attention, although its control is ...

Senior Editor; The University of Texas at Austin, United States Our editorial process produces two outputs: i) public reviews designed to be posted alongside the preprint for the benefit of readers; ...

ABSTRACT: Impaired excitation-contraction coupling occurs in eccentric contraction (ECC)-induced damaged muscles. It has been suggested that sarcoplasmic reticulum (SR) is susceptible to damage in the ...

Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP 3-receptor (IP 3 R) calcium channels are necessary for the mitochondrial Ca 2+ increase caused by membrane depolarization induced ...

The possibility that the inotropic action of epinephrine might be mediated through an effect on the excitation-contraction coupling process was explored, using techniques for measurement of isometric ...