EurekAlert!6mon
Increased systemic iron levels induce the expression of hepcidin via TfR/Hfe (IMAGE)
Inflammatory signals via IL-6 through the JAK-STAT cascade induce the expression of the Hepcidin gene (HAMP). Higher EPO and HIF lead to the secretion of ERFE from erythroid precursor cells ...
Nature1mon
Regulation of iron acquisition and storage: consequences for iron-linked disorders
Hepcidin, a peptide hormone secreted by the ... For example, injecting soluble HJV into mice results in inhibition of Hamp gene transcription and thereby increases iron acquisition and utilization ...
Hosted on MSN3mon
Regulating iron overload: Liraglutide's potential benefits
Hepcidin, which is encoded by the Hamp gene, regulates the absorption of iron from the intestines, recycling by macrophages, and release of stored iron from hepatocytes. The protein HFE regulates ...
EurekAlert!10mon
Schematic diagram illustrating the possible mechanism of SMURF1 in serum iron overload (Created with bioRender.com) (IMAGE)
BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; HAMP, hepcidin; HFE, hereditary hemochromatosis protein; HJV, hemojuvelin; Holo-Tf, holo ...