Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ-PKAc fusion oncoprotein. However, the underlying mechanism of DNAJ-PKAc’s ...

Explore the impact of 3D models in drug discovery and how they enhance predictive insights in pre-clinical research.

A new study looking at deadly animal African trypanosomiasis has revealed how the parasite Trypanosoma congolense evades the ...

Ahead of AACR 2025, Charles River announces updates to its comprehensive portfolio to support the discovery and development of novel oncology drugs.

In vitro technologies like 3D organoids and high-content imaging are advancing immuno-oncology by enabling detailed ...

During morphogenesis—the process by which living organisms take shape—cells collectively position themselves in specific ways ...

Sclerosteosis is a rare genetic disorder that causes excessive bone growth, leading to life-altering complications, including hearing loss and facial paralysis.

New research from the Royal Veterinary College (RVC) has identified porcupine inhibition—a strategy that blocks a key ...

To address this shortcoming, 3D cell culture enthusiasts are tackling the challenge by developing robust in vitro human models ... “We are recreating the 2D paradigm in terms of scaling and ...

Researchers discuss how organoids and organ-on-a-chip technologies are transforming women’s health research. By mimicking ...

Using in-vitro models of a specific type of brain cell, scientists have demonstrated that neurons can transform from one type to another. Neurons are specialized brain cells responsible for ...