C&EN20d
Same FeN4 Active Site, Different Activity: How Redox Peaks Control Oxygen Reduction on Fe Macrocycles
However, even macrocycles with the same metal centers and MN4 active site can vary significantly in activity and selectivity, and to this date, a quantitative insight into the cause of these ...
The EMBO Journal20d
TRIM32 regulates insulin sensitivity by controlling insulin receptor degradation in the liver
In this study, we identify an E3 ubiquitin ligase, tripartite motif-containing protein 32 (TRIM32), as a key regulator ... sensitivity and reverses fatty liver Altered INSR levels and kinase activity ...
C&EN24d
Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights
Helmholtz Institute for Pharmaceutical Research (HIPS)−Helmholtz Centre for Infection Research (HZI), Saar-land University, Campus E8.1, 66123Saarbrücken, Germany Department of Pharmacy, Saarland ...
Washington Times26d
No shots fired, no injuries after ‘active incident’ reported at Louisiana mall, police say
A Louisiana mall was the site of an apparent false alarm about an active shooter just two days after the carnage in New Orleans. A Lafayette Police spokesman confirmed to the Acadiana Advocate ...
Cancer Research28d
Phase I/II Study of the Aurora Kinase A Inhibitor Alisertib and Pembrolizumab in Refractory, Rb-Deficient Head and Neck Squamous Cell Carcinomas
1Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2The University of Texas MD Anderson Cancer Center, UTHealth Houston Graduate ...
Nature29d
Structure-based discovery of antibacterial drugs
AutoDock is a suite of automated docking ... site. LUDI. LUDI, another module in Discovery Studio, constructs possible new ligands for a given protein of known three-dimensional structure.