Safer and more broadly effective rotavirus vaccines could be achieved if initial investigations 1 into the boosting effect of plant-derived virus-like particles hold up in further trials.

The resulting chimeric P particles also maintained the major ... P particle–VP8* chimera as a promising dual vaccine against rotavirus and NoV and the P particle–M2e chimera against influenza ...

The authors generated a three-dimensional reconstruction of VP6 from 8,400 images of rotavirus particles using the computer program FREALIGN. The positions and conformations of many amino acid ...

Researchers at Baylor College of Medicine and collaborating institutions have improved our understanding of how rotavirus, ...

Our studies using monoclonal antibodies, reassortants, and baculovirus-expressed virus-like particles have provided insights into the molecular mechanisms of cell entry, infectivity, transcription, ...

The resulting chimeric P particles also maintained the major antigenic epitopes of the P particles, allowing the production of dual vaccine against NoV and the inserted antigens to be developed.