Leukocyte–Endothelial Cell Adhesion - Inflammation and the ...
Endothelial cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin can be detected on the surface of activated ECs in arterioles and occasionally capillaries; however, the density of these adhesion molecules is far greater on venular endothelium.
Endothelial Cell Junctional Adhesion Molecules: Role and ...
Enzymatic cleavage and shedding from the cell surface reduces the expression of junctional adhesion molecules at endothelial cell junctions. The mechanisms illustrated in the diagram can regulate inflammatory responses such as vascular leakage, and the magnitude and profile of leukocyte TEM.
Cell Adhesion Molecules and Their Roles and Regulation in the ...
Indeed, down-regulation of adhesion molecules on tumor-associated endothelial cells, a process termed as endothelial anergy, is an effective mechanism utilized by tumors to prevent immune cell trafficking into the tumor site (102, 103).
Endothelial cell-cell adhesion and signaling - PMC
Sep 9, 2017 · During transendothelial migration, endothelial adhesion molecules ICAM-1, VCAM-1 and PECAM-1 interact with leukocytes and transmit signals into the endothelial cell (bottom panel), which promote the transmigration process.
Endothelial Cell Junctional Adhesion Molecules: Role and ...
This review summarizes key aspects of our current understanding of the dynamics and mechanisms that regulate the expression of endothelial cells junctional molecules during inflammation and discusses the associated functional implications of such events in acute and chronic scenarios.
Endothelial adhesion molecules and their role in inflammation
Once the marginated neutrophil forms a stationary adhesion with endothelial cells, it is stimulated by chemotactic factors to downregulate the selectin-based adhesion and upregulate adherence dependent on beta 2-integrins, principally CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1).
Adhesion Molecules and Endothelium - ScienceDirect
Jan 1, 2018 · Signal transduction mechanisms within endothelial cells are mediated by immunoglobulin type cell adhesion molecules (IgCAM), which affect not only leukocyte-endothelium interactions, but also those between endothelial cells.